CVC is a small biocompatible tube or vascular access device made of soft flexible material inserted into a large vein of the peripheral vascular system and tip of the catheter advanced into the superior vena cava (SVC). The catheter insertion site may be an upper extremity, jugular vein or subclavian vein. Radiographic studies are necessary to confirm CVC placement. Subclavian or axillary tip placement: not considered as a CVC. SVC placement is required for administration of TPN and continues infusion of volume, toxic chemotherapy agents. See also Central Line.