A curve that shows the relationship between the partial pressure of oxygen and the percentage of saturation of hemoglobin with oxygen. Left shift – factors that shift the curve to the left include a decrease in temperature (hence temperature management for maximum oxygen in tissues), a decrease in carbon dioxide tension, and an increase in pH. Such factors cause an increase in affinity of hemoglobin for oxygen, and increased oxygen-binding capacity. Right shift – factors that favor a shift of the curve to the right. Accelerating the release of oxygen from oxyhemoglobin, are a rise in temperature (increased oxygen released to tissues increases collagen deposition for scar strength oxydative radical killing capability for neutrophils and enhanced mobility for macrophages), an increase in carbon dioxide tension, and a decrease in pH. These factors cause a decrease in the affinity of hemoglobin for oxygen and decreased oxygen-binding capacity so it can be released in the tissues. SEE hemoglobin saturation curve.