Are medications that stop the stomachs acid pump. Examples are omeprazole (Prilosec), lansoprazole (Prevacid), and rabeprazole (Aciphex). These drugs may be used for gastroesophageal reflux disease (GERD), and peptic ulcer disease. The use of these drugs has been associated with an increase in C. difficile infections as the reduction in acid allows the vegetative C. difficile to survive and reach the intestines. Normal stomach acids destroy the vegetative forms, but have no affect on the spore form.